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Relationships between the material properties of silicone hydrogels: Desiccation, wettability and lubricity.

ABSTRACT: Silicone hydrogels (SiHy), represent composite matrices composed of hydrophobic gas permeable silicone (Si) rich core and a surface enriched with hydrophilic polymer moieties. Their utilization in contact lens design requires number of SiHy properties (hydration, wettability, lubricity) to be optimized for the challenging conditions at the ocular surface. Typical limitations in literature are that (i) these properties are studied in isolation, monitoring only one parameter but not the rest of them, and (ii) measurements are performed with hydrated samples immediately after removal from storage solutions. Here we study the simultaneous evolution of critical material properties (evaporative loss of water, water contact angle, coefficient of friction) of different SiHy subjected to continuous blink-like desiccation/rehydration cycling. SiHy with wetting agents incorporated in their core (narafilcon A, senofilcon A) were particularly susceptible to extended desiccation. Stenfilcon A, a material with only 3% bulk Si content maintained its performance for 4?h of cycling, and delefilcon A (80% surface water content) resisted extended 8?h of desiccation/rehydration runs. Strong correlation exists between the evolution of SiHy wettability and lubricity at ?4?h of blink-like cycling. Understanding the interplay between SiHy properties bears insights for knowledge based design of novel ophthalmic materials.

SUBMITTER: Eftimov PB

PROVIDER: S-EPMC7917563 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Relationships between the material properties of silicone hydrogels: Desiccation, wettability and lubricity.

Eftimov Petar Borisov PB Yokoi Norihiko N Peev Nikola N Paunski Yasen Y Georgiev Georgi Asenov GA

Journal of biomaterials applications 20201101 8

Silicone hydrogels (SiHy), represent composite matrices composed of hydrophobic gas permeable silicone (Si) rich core and a surface enriched with hydrophilic polymer moieties. Their utilization in contact lens design requires number of SiHy properties (hydration, wettability, lubricity) to be optimized for the challenging conditions at the ocular surface. Typical limitations in literature are that (i) these properties are studied in isolation, monitoring only one parameter but not the rest of th ...[more]

PMID: 33135571

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Relationships between the material properties of silicone hydrogels: Desiccation, wettability and lubricity.

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Relationships between the material properties of silicone hydrogels: Desiccation, wettability and lubricity.

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