Ontology highlight
ABSTRACT:
SUBMITTER: Mroweh M
PROVIDER: S-EPMC7917860 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Mroweh Mariam M Roth Gaël G Decaens Thomas T Marche Patrice N PN Lerat Hervé H Macek Jílková Zuzana Z
International journal of molecular sciences 20210211 4
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide, and its incidence is rising. HCC develops almost exclusively on the background of chronic liver inflammation, which can be caused by chronic alcohol consumption, viral hepatitis, or an unhealthy diet. The key role of chronic inflammation in the process of hepatocarcinogenesis, including in the deregulation of innate and adaptive immune responses, has been demonstrated. The inhibition of Akt (also ...[more]