Ontology highlight
ABSTRACT:
SUBMITTER: Nasillo V
PROVIDER: S-EPMC7918142 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nasillo Vincenzo V Riva Giovanni G Paolini Ambra A Forghieri Fabio F Roncati Luca L Lusenti Beatrice B Maccaferri Monica M Messerotti Andrea A Pioli Valeria V Gilioli Andrea A Bettelli Francesca F Giusti Davide D Barozzi Patrizia P Lagreca Ivana I Maffei Rossana R Marasca Roberto R Potenza Leonardo L Comoli Patrizia P Manfredini Rossella R Maiorana Antonino A Tagliafico Enrico E Luppi Mario M Trenti Tommaso T
International journal of molecular sciences 20210214 4
The Philadelphia-negative myeloproliferative neoplasms (MPNs) are malignancies of the hematopoietic stem cell (HSC) arising as a consequence of clonal proliferation driven by somatically acquired driver mutations in discrete genes (JAK2, CALR, MPL). In recent years, along with the advances in molecular characterization, the role of immune dysregulation has been achieving increasing relevance in the pathogenesis and evolution of MPNs. In particular, a growing number of studies have shown that MPN ...[more]