Ontology highlight
ABSTRACT:
SUBMITTER: Leroux C
PROVIDER: S-EPMC7918504 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Leroux Cédric C Konstantinidou Georgia G
Cancers 20210214 4
Cytotoxic chemotherapy remains the only treatment option for most pancreatic ductal adenocarcinoma patients. Currently, the median overall survival of patients with advanced disease rarely exceeds 1 year. The complex network of pancreatic cancer composed of immune cells, endothelial cells, and cancer-associated fibroblasts confers intratumoral and intertumoral heterogeneity with distinct proliferative and metastatic propensity. This heterogeneity can explain why tumors do not behave uniformly an ...[more]