Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity.
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ABSTRACT:
SUBMITTER: Ferraro G
PROVIDER: S-EPMC7918638 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity.
Ferraro Giarita G Pratesi Alessandro A Cirri Damiano D Imbimbo Paola P Maria Monti Daria D Messori Luigi L Merlino Antonello A
International journal of molecular sciences 20210213 4
Arsenoplatin-1 (AP-1), the prototype of a novel class of metallodrugs containing a PtAs(OH)<sub>2</sub> core, was encapsulated within the apoferritin (AFt) nanocage. UV-Vis absorption spectroscopy and inductively coupled plasma-atomic emission spectroscopy measurements confirmed metallodrug encapsulation and allowed us to determine the average amount of AP-1 trapped inside the cage. The X-ray structure of AP-1-encapsulated AFt was solved at 1.50 Å. Diffraction data revealed that an AP-1 fragment ...[more]
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