Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis.
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ABSTRACT:
SUBMITTER: Teo YJ
PROVIDER: S-EPMC7918719 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
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Renal CD169<sup>++</sup> resident macrophages are crucial for protection against acute systemic candidiasis.
Teo Yi Juan YJ Ng See Liang SL Mak Keng Wai KW Setiagani Yolanda Aphrilia YA Chen Qi Q Nair Sajith Kumar SK Sheng Jianpeng J Ruedl Christiane C
Life science alliance 20210219 5
Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival, much less is known for the protective role elicited by the tissue-resident macrophage (TRM) subsets in the kidney, the prime organ for <i>Candida</i> persistence. Here, we describe a unique CD169<sup ...[more]
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