A Systems Biology Approach to Identify Essential Epigenetic Regulators for Specific Biological Processes in Plants.

ABSTRACT: Upon sensing developmental or environmental cues, epigenetic regulators transform the chromatin landscape of a network of genes to modulate their expression and dictate adequate cellular and organismal responses. Knowledge of the specific biological processes and genomic loci controlled by each epigenetic regulator will greatly advance our understanding of epigenetic regulation in plants. To facilitate hypothesis generation and testing in this domain, we present EpiNet, an extensive gene regulatory network (GRN) featuring epigenetic regulators. EpiNet was enabled by (i) curated knowledge of epigenetic regulators involved in DNA methylation, histone modification, chromatin remodeling, and siRNA pathways; and (ii) a machine-learning network inference approach powered by a wealth of public tr

SUBMITTER: McCoy RM 

PROVIDER: S-EPMC7918732 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature