Ontology highlight
ABSTRACT:
SUBMITTER: Michaux H
PROVIDER: S-EPMC7919294 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Michaux Hélène H Halouani Aymen A Trussart Charlotte C Renard Chantal C Jaïdane Hela H Martens Henri H Geenen Vincent V Hober Didier D
Microorganisms 20210215 2
Coxsackievirus B4 (CV-B4) can infect human and murine thymic epithelial cells (TECs). In a murine TEC cell line, CV-B4 can downregulate the transcription of the insulin-like growth factor 2 (<i>Igf2</i>) gene coding for the self-peptide of the insulin family. In this study, we show that CV-B4 infections of a murine TEC cell line decreased <i>Igf2</i> P3 promoter activity by targeting a region near the transcription start site; however, the stability of <i>Igf2</i> transcripts remained unchanged, ...[more]