Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks.
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ABSTRACT:
SUBMITTER: Sinturel F
PROVIDER: S-EPMC7919413 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Circadian hepatocyte clocks keep synchrony in the absence of a master pacemaker in the suprachiasmatic nucleus or other extrahepatic clocks.
Sinturel Flore F Gos Pascal P Petrenko Volodymyr V Hagedorn Claudia C Kreppel Florian F Storch Kai-Florian KF Knutti Darko D Liani Andre A Weitz Charles C Emmenegger Yann Y Franken Paul P Bonacina Luigi L Dibner Charna C Schibler Ueli U
Genes & development 20210218 5-6
It has been assumed that the suprachiasmatic nucleus (SCN) synchronizes peripheral circadian oscillators. However, this has never been convincingly shown, since biochemical time series experiments are not feasible in behaviorally arrhythmic animals. By using long-term bioluminescence recording in freely moving mice, we show that the SCN is indeed required for maintaining synchrony between organs. Surprisingly, however, circadian oscillations persist in the livers of mice devoid of an SCN or osci ...[more]
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