Ontology highlight
ABSTRACT:
SUBMITTER: Locquet MA
PROVIDER: S-EPMC7919493 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Locquet Marie-Anaïs MA Dechaume Anne-Lise AL Berchard Paul P Abbes Lhorra L Pissaloux Daniel D Tirode Franck F Ramos Inès I Bedoucha Julie J Valantin Julie J Karanian Marie M Perret Raul R Gille Olivier O Blay Jean-Yves JY Dutour Aurélie A
Cells 20210215 2
Chordomas are rare, slow-growing tumors of the axial skeleton. These tumors are locally aggressive and refractory to conventional therapies. Radical surgery and radiation remain the first-line treatments. Despite these aggressive treatments, chordomas often recur and second-line treatment options are limited. The mechanisms underlying chordoma radioresistance remain unknown, although several radioresistant cancer cells have been shown to respond favorably to aldehyde dehydrogenase (ALDH) inhibit ...[more]