Ontology highlight
ABSTRACT:
SUBMITTER: Scheffel TB
PROVIDER: S-EPMC7919594 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Scheffel Thamiris Becker TB Grave Nathália N Vargas Pedro P Diz Fernando Mendonça FM Rockenbach Liliana L Morrone Fernanda Bueno FB
Frontiers in oncology 20210215
Glioblastoma is the most malignant and lethal subtype of glioma. Despite progress in therapeutic approaches, issues with the tumor immune landscape persist. Multiple immunosuppression pathways coexist in the tumor microenvironment, which can determine tumor progression and therapy outcomes. Research in immune checkpoints, such as the PD-1/PD-L1 axis, has renewed the interest in immune-based cancer therapies due to their ability to prevent immunosuppression against tumors. However, PD-1/PD-L1 blo ...[more]