Dataset Information

Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, Mexico.

ABSTRACT: Environmental arsenic exposure in adults and children has been associated with a reduction in the expression of club cell secretory protein (CC16) and an increase in the expression of matrix metalloproteinase-9 (MMP-9), both biomarkers of lung inflammation and negative respiratory outcomes. The objectives of this study were to determine if the levels of serum CC16 and MMP-9 and subsequent respiratory infections in children are associated with the ingestion of arsenic by drinking water. This cross-sectional study included 216 children from three Yaqui villages, Potam, Vicam, and Cocorit, with levels of arsenic in their ground water of 70.01 ± 21.85, 23.3 ± 9.99, and 11.8 ± 4.42 ?g/L respectively. Total arsenic in water and urine samples was determined by inductively coupled plasma/optical emission spectrometry. Serum was analyzed for CC16 and MMP-9 using ELISA. The children had an average urinary arsenic of 79.39 ?g/L and 46.8 % had levels above of the national concern value of 50 ?g/L. Increased arsenic concentrations in drinking water and average daily arsenic intake by water were associated with decreased serum CC16 levels (? = - 0.12, 95% CI - 0.20, - 0.04 and ? = - 0.10, 95% CI - 0.18, - 0.03), and increased serum MMP-9 levels (? = 0.35, 95% CI 0.22, 0.48 and ? = 0.29, 95% CI 0.18, 0.40) at significant levels (P < 0.05). However, no association was found between levels of these serum biomarkers and urinary arsenic concentrations. In these children, reduced serum CC16 levels were significantly associated with increased risk of respiratory infections (OR = 0.34, 95% CI 0.13, 0.90). In conclusion, altered levels of serum CC16 and MMP-9 in the children may be due to the toxic effects of arsenic exposure through drinking water.

SUBMITTER: Vega-Millan CB

PROVIDER: S-EPMC7919633 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México.

Vega-Millán Christian B CB Dévora-Figueroa Ana G AG Burgess Jefferey L JL Beamer Paloma I PI Furlong Melissa M Lantz R Clark RC Meza-Figueroa Diana D O Rourke Mary Kay MK García-Rico Leticia L Meza-Escalante Edna R ER Balderas-Cortés José J JJ Meza-Montenegro Maria M MM

Environmental science and pollution research international 20210301 26

Environmental arsenic exposure in adults and children has been associated with a reduction in the expression of club cell secretory protein (CC16) and an increase in the expression of matrix metalloproteinase-9 (MMP-9), both biomarkers of lung inflammation and negative respiratory outcomes. The objectives of this study were to determine if the levels of serum CC16 and MMP-9 and subsequent respiratory infections in children are associated with the ingestion of arsenic by drinking water. This cros ...[more]

PMID: 33650048

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Project description:ObjectivesCollate published evidence of factors that affect maternal health in Indigenous communities and contextualise the findings with stakeholder perspectives in the Mexican State of Guerrero.DesignScoping review and stakeholder fuzzy cognitive mapping.Inclusion and exclusionThe scoping review included empirical studies (quantitative, qualitative or mixed methods) that addressed maternal health issues among Indigenous communities in the Americas and reported on the role or influence of traditional midwives before June 2020. The contextualisation drew on two previous studies of traditional midwife and researcher perspectives in southern Mexico.ResultsThe initial search identified 4461 references. Of 87 selected studies, 63 came from Guatemala and Mexico. Three small randomised trials involved traditional midwives. One addressed the practice of traditional midwifery. With diverse approaches to cultural differences, the studies used contrasting definitions of traditional midwives. A fuzzy cognitive map graphically summarised the influences identified in the scoping review. When we compared the literature's map with those from 29 traditional midwives in Guerrero and eight international researchers, the three sources coincided in the importance of self-care practices, rituals and traditional midwifery. The primary concern reflected in the scoping review was access to Western healthcare, followed by maternal health outcomes. For traditional midwives, the availability of hospital or health centre in the community was less relevant and had negative effects on other protective influences, while researchers conditioned its importance to its levels of cultural safety. Traditional midwives highlighted the role of violence against women, male involvement and traditional diseases.ConclusionsThe literature and stakeholder maps showed maternal health resulting from complex interacting factors in which promotion of cultural practices was compatible with a protective effect on Indigenous maternal health. Future research challenges include traditional concepts of diseases and the impact on maternal health of gender norms, self-care practices and authentic traditional midwifery.

Project description:Southern Mexico's tropical forests are home to the country's highest richness of mammal species; La Chinantla region is situated within this area, its name from the indigenous group residing in the area and holding territorial ownership, namely the Chinantecos. In La Chinantla, there are no Protected Areas; instead, there are Areas Destined Voluntarily for Conservation (ADVC) and "Voluntary Conservation Areas" (VCA), that are managed by local inhabitants through social consensus. These ADVC may function as an archipelago reserve, which represents regional diversity, including the social context, through complementarity. To verify its biodiversity, we analyzed the richness, composition, distribution, and conservation of wild mammals in the region. Records were obtained from four sources-primary data collection, databases, scientific literature, and community monitoring-and were organized into four zones based on altitudinal and vegetation gradients. We compared the diversity between zones for three categories of mammals: small (<100 gr.), bats, and medium and large (>100 gr.). 134 species were identified comprising 11 orders, 26 families and 86 genera. The zone with highest elevation presented the greatest species richness for the assemblage of mammals and terrestrial mammals, while the zone with the lowest elevation had the highest richness of bats. For each mammal category, the zone with the most species also registered the highest number of exclusive species. For the assemblage of mammals and for medium and large mammals, the similarity index was highest between the two intermediate zones, while for small mammals and bats, the greatest similarity occurred between the areas of higher altitude. The study region was found to have the second highest richness of mammals in Mexico. Finally, we suggest that the conservation proposals by indigenous people could function as a set of "islands" that promote the conservation of biodiversity, possibly as an Archipelago Reserve.

Dataset Information

Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, Mexico.

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Inflammation biomarkers associated with arsenic exposure by drinking water and respiratory outcomes in indigenous children from three Yaqui villages in southern Sonora, México.

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