Ontology highlight
ABSTRACT:
SUBMITTER: Furlong-Silva J
PROVIDER: S-EPMC7919730 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Furlong-Silva Julio J Cross Stephen D SD Marriott Amy E AE Pionnier Nicolas N Archer John J Steven Andrew A Merker Stefan Schulte SS Mack Matthias M Hong Young-Kwon YK Taylor Mark J MJ Turner Joseph D JD
The Journal of clinical investigation 20210301 5
Lymphatic filariasis is the major global cause of nonhereditary lymphedema. We demonstrate that the filarial nematode Brugia malayi induced lymphatic remodeling and impaired lymphatic drainage following parasitism of limb lymphatics in a mouse model. Lymphatic insufficiency was associated with elevated circulating lymphangiogenic mediators, including vascular endothelial growth factor C. Lymphatic insufficiency was dependent on type 2 adaptive immunity, the interleukin-4 receptor, and recruitmen ...[more]