Ontology highlight
ABSTRACT:
SUBMITTER: Lhuillier C
PROVIDER: S-EPMC7919731 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Lhuillier Claire C Rudqvist Nils-Petter NP Yamazaki Takahiro T Zhang Tuo T Charpentier Maud M Galluzzi Lorenzo L Dephoure Noah N Clement Cristina C CC Santambrogio Laura L Zhou Xi Kathy XK Formenti Silvia C SC Demaria Sandra S
The Journal of clinical investigation 20210301 5
Neoantigens generated by somatic nonsynonymous mutations are key targets of tumor-specific T cells, but only a small number of mutations predicted to be immunogenic are presented by MHC molecules on cancer cells. Vaccination studies in mice and patients have shown that the majority of neoepitopes that elicit T cell responses fail to induce significant antitumor activity, for incompletely understood reasons. We report that radiotherapy upregulates the expression of genes containing immunogenic mu ...[more]