Ontology highlight
ABSTRACT:
SUBMITTER: Hegedus L
PROVIDER: S-EPMC7920251 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Hegedüs Luca L Okumus Özlem Ö Livingstone Elisabeth E Baranyi Marcell M Kovács Ildikó I Döme Balázs B Tóvári József J Bánkfalvi Ágnes Á Schadendorf Dirk D Aigner Clemens C Hegedüs Balázs B
Cancers 20210216 4
Spitzoid melanoma is a rare malignancy with histological characteristics similar to Spitz nevus. It has a diverse genetic background and in adults, a similarly grim clinical outcome as conventional malignant melanoma. We established a spitzoid melanoma cell line (PF130) from the pleural effusion sample of a 37-year-old male patient. We found that the cell line carries a rare MEK1 mutation (pGlu102_Lys104delinsGln) that belongs to the RAF- and phosphorylation-independent subgroup of MEK1 alternat ...[more]