Ontology highlight
ABSTRACT:
SUBMITTER: Linehan AS
PROVIDER: S-EPMC7920506 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Linehan Anna S AS Fitzpatrick Orla M OM Morris Patrick G PG
Breast cancer (Dove Medical Press) 20210225
Trastuzumab deruxtecan is a novel antibody-drug conjugate for the treatment of advanced solid tumors, including breast cancer, which overexpress or have amplification of the human epidermal growth factor receptor 2 (HER2). The novel structure of this exciting new agent means that it can deliver a highly potent cytotoxic agent to HER2-expressing tissues resulting in selective killing of cancer cells. In phase I and II trials, trastuzumab deruxtecan has shown impressive response rates in heavily p ...[more]