Oral Human Papillomavirus Infection in Children during the First 6 Years of Life, Finland.
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ABSTRACT:
SUBMITTER: Syrjanen S
PROVIDER: S-EPMC7920652 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Oral Human Papillomavirus Infection in Children during the First 6 Years of Life, Finland.
Syrjänen Stina S Rintala Marjut M Sarkola Marja M Willberg Jaana J Rautava Jaana J Koskimaa Hanna H Paaso Anna A Syrjänen Kari K Grénman Seija S Louvanto Karolina K
Emerging infectious diseases 20210129 3
Human papillomavirus (HPV) infections are found in children, but transmission modes and outcomes are incompletely understood. We evaluated oral samples from 331 children in Finland who participated in the Finnish Family HPV Study from birth during 9 follow-up visits (mean time 51.9 months). We tested samples for 24 HPV genotypes. Oral HPV prevalence for children varied from 8.7% (at a 36-month visit) to 22.8% (at birth), and 18 HPV genotypes were identified. HPV16 was the most prevalent type to ...[more]
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Project description:BackgroundPrematurity in itself and exposure to neonatal intensive care triggers inflammatory processes and oxidative stress, leading to risk for disease later in life. The effects on cellular aging processes are incompletely understood.MethodsRelative telomere length (RTL) was measured by qPCR in this longitudinal cohort study with blood samples taken at birth and at 2 years of age from 60 children (16 preterm and 44 term). Viral respiratory infections the first year were evaluated. Epigenetic biological DNA methylation (DNAm) age was predicted based on methylation array data in 23 children (11 preterm and 12 term). RTL change/year and DNAm age change/year was compared in preterm and term during the 2 first years of life.ResultsPreterm infants had longer telomeres than term born at birth and at 2 years of age, but no difference in telomere attrition rate could be detected. Predicted epigenetic DNAm age was younger in preterm infants, but rate of DNAm aging was similar in both groups.ConclusionsDespite early exposure to risk factors for accelerated cellular aging, children born preterm exhibited preserved telomeres. Stress during the neonatal intensive care period did not reflect accelerated epigenetic DNAm aging. Early-life aging was not explained by preterm birth.ImpactPreterm birth is associated with elevated disease risk later in life. Preterm children often suffer from inflammation early in life. Stress-related telomere erosion during neonatal intensive care has been proposed. Inflammation-accelerated biological aging in preterm is unknown. We find no accelerated aging due to prematurity or infections during the first 2 years of life.
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