Ontology highlight
ABSTRACT:
SUBMITTER: Xie B
PROVIDER: S-EPMC7920988 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Advances in biological regulation 20210105
Arf GTPase activating (ArfGAP) proteins are critical regulatory and effector proteins in membrane trafficking pathways. Budding yeast contain two ArfGAP proteins (Gcs1 and Glo3) implicated in COPI coat function at the Golgi, and yeast require Glo3 catalytic function for viability. A new X-ray crystal structure of the Glo3 GAP domain was determined at 2.1 Å resolution using molecular replacement methods. The structure reveals a Cys<sub>4</sub>-family zinc finger motif with an invariant residue (R ...[more]