Ontology highlight
ABSTRACT:
SUBMITTER: Weng M
PROVIDER: S-EPMC7921329 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Weng Mingjiao M Feng Yukuan Y He Yan Y Yang Weiwei W Li Jing J Zhu Yuanyuan Y Wang Tianzhen T Wang Chuhan C Zhang Xiao X Qiao Yu Y Li Qi Q Zhao Lingyu L Gao Shuangshu S Zhang Lei L Wu Yiqi Y Zhao Ran R Wang Guangyu G Li Zhiwei Z Jin Xiaoming X Zheng Tongsen T Li Xiaobo X
Frontiers in cell and developmental biology 20210216
The hypoxic microenvironment is beneficial to the metastasis but not to the proliferation of cancer cells. However, the mechanisms regarding to hypoxia differentially regulating cancer metastasis and proliferation are largely unknown. In this study, we revealed that hypoxia induced the expression of LIN28A at mRNA level but segregated LIN28A mRNAs in the P-bodies and thus inhibits the production of LIN28A protein. This unexpected finding suggests that there may be non-coding role for LIN28A mRNA ...[more]