Alternative splicing events implicated in carcinogenesis and prognosis of thyroid gland cancer.
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ABSTRACT:
SUBMITTER: Wu ZH
PROVIDER: S-EPMC7921437 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Alternative splicing events implicated in carcinogenesis and prognosis of thyroid gland cancer.
Wu Zeng-Hong ZH Tang Yun Y Zhou Yue Y
Scientific reports 20210301 1
Alternative splicing (AS), a critical post-transcriptional regulatory mechanism, expands gene expression patterns, thereby leading to increased protein diversity. Indeed, more than 95% of human genes undergo alternative splicing events (ASEs). In this study, we drew an all-around AS profile of thyroid cancer cells based on RNA-seq data. In total, there were 45,150 AS in 10,446 thyroid cancer cell genes derived from 506 patients, suggesting that ASEs is a common process in TC. Moreover, 1819 AS s ...[more]
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