Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC7921578 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Li Wang W Liu Xin X Qiao Hui H
Acta pharmacologica Sinica 20200407 12
Sirtuin 6 (SIRT6) has been reported to play a key role in cognitive function and mood regulation, yet its role in mood disorders is not completely understood. Here, we confirmed that knockdown of hippocampal SIRT6 alleviated depression-like behaviors induced by chronic unpredictable stress (CUS) in mice. Our in vitro data showed that SIRT6 negatively regulated protein kinase B (AKT) signaling by deacetylating histone 3 at Lys9 and Lys56. Knockdown of SIRT6 significantly increased AKT phosphoryla ...[more]