Dataset Information

Automated solubility screening platform using computer vision.

ABSTRACT: Solubility screening is an essential, routine process that is often labor intensive. Robotic platforms have been developed to automate some aspects of the manual labor involved. However, many of the existing systems rely on traditional analytic techniques such as high-performance liquid chromatography, which require pre-calibration for each compound and can be resource consuming. In addition, automation is not typically end-to-end, requiring user intervention to move vials, establish analytical methods for each compound and interpret the raw data. We developed a closed-loop, flexible robotic system with integrated solid and liquid dosing capabilities that relies on computer vision and iterative feedback to successfully measure caffeine solubility in multiple solvents. After initial researcher input (<2 min), the system ran autonomously, screening five different solvent systems (20-80 min each). The resulting solubility values matched those obtained using traditional manual techniques.

SUBMITTER: Shiri P

PROVIDER: S-EPMC7921605 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Automated solubility screening platform using computer vision.

Shiri Parisa P Lai Veronica V Zepel Tara T Griffin Daniel D Reifman Jonathan J Clark Sean S Grunert Shad S Yunker Lars P E LPE Steiner Sebastian S Situ Henry H Yang Fan F Prieto Paloma L PL Hein Jason E JE

iScience 20210212 3

Solubility screening is an essential, routine process that is often labor intensive. Robotic platforms have been developed to automate some aspects of the manual labor involved. However, many of the existing systems rely on traditional analytic techniques such as high-performance liquid chromatography, which require pre-calibration for each compound and can be resource consuming. In addition, automation is not typically end-to-end, requiring user intervention to move vials, establish analytical ...[more]

PMID: 33718828

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Dataset Information

Automated solubility screening platform using computer vision.

Publications

Automated solubility screening platform using computer vision.

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