Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer's disease.

ABSTRACT: To characterize rod- and cone-pathway function in the 5xFAD mouse model of Alzheimer's disease (AD) using the full-field electroretinogram (ERG). Dark-adapted (DA; rod-pathway) and light-adapted (LA; cone-pathway) ERGs were recorded from three-month-old 5xFAD and wild type (WT) mice. ERGs were elicited by achromatic flashes (0.01-25 cd-s-m^-2). Amplitude and implicit time (IT) of the a-wave, b-wave, and oscillatory potentials (OPs) were calculated according to convention. In addition, the amplitude and IT of the photopic negative response (PhNR) were measured from the LA recordings. Amplitude and IT differences between the 5xFAD and WT groups were evaluated using quantile regression models. Under DA conditions, there were significant differences between the 5xFAD and WT groups in post-receptor function, whereas photoreceptor function did not differ significantly. Specifically, the DA a-wave amplitude did not differ between groups (p?=?0.87), whereas the b-wave amplitude was reduced in the 5xFAD mice (p?=?0.003). There were significant OP (p?

SUBMITTER: McAnany JJ 

PROVIDER: S-EPMC7921657 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature