Spatial patterns of lower respiratory tract infections and their association with fine particulate matter.

ABSTRACT: This study aimed to identify the spatial patterns of lower respiratory tract infections (LRIs) and their association with fine particulate matter (PM_2.5). The disability-adjusted life year (DALY) database was used to represent the burden each country experiences as a result of LRIs. PM_2.5 data obtained from the Atmosphere Composition Analysis Group was assessed as the source for main exposure. Global Moran's I and Getis-Ord Gi* were applied to identify the spatial patterns and for hotspots analysis of LRIs. A generalized linear mixed model was coupled with a sensitivity test after controlling for covariates to estimate the association between LRIs and PM_2.5. Subgroup analyses were performed to determine whether LRIs and PM_2.5 are correlated for various ages and geographic regions. A significant spatial auto-correlated pattern was identified for global LRIs with Moran's Index 0.79, and the hotspots of LRIs were clustered in 35 African and 4 Eastern Mediterranean countries. A consistent significant positive association between LRIs and PM_2.5 with a coefficient of 0.21 (95% CI 0.06-0.36) was identified. Furthermore, subgroup analysis revealed a significant effect of PM_2.5 on LRI for children (0-14 years) and the elderly (??70 years), and this effect was confirmed to be significant in all regions except for those comprised of Eastern Mediterranean countries.

SUBMITTER: Asri AK 

PROVIDER: S-EPMC7921673 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature