Ontology highlight
ABSTRACT:
SUBMITTER: Jiang CT
PROVIDER: S-EPMC7921676 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Jiang Cheng-Tao CT Chen Kai-Ge KG Liu An A Huang Hua H Fan Ya-Nan YN Zhao Dong-Kun DK Ye Qian-Ni QN Zhang Hou-Bing HB Xu Cong-Fei CF Shen Song S Xiong Meng-Hua MH Du Jin-Zhi JZ Yang Xian-Zhu XZ Wang Jun J
Nature communications 20210301 1
Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T cells and tumor cells via chimeric antigen receptor- T cells or bispecific T cell-engaging antibodies are two typical cancer immunotherapy approaches. We speculated that immobilizing two types of mAbs against effector cells and tumor cells on a single nanoparticle could integrate the functions of these two approaches, as the engineered formulation (immunomodulating nano-adaptor, imNA) could ...[more]