Dataset Information
Development and validation of a novel staging system integrating the number and location of lymph nodes for gastric adenocarcinoma.
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ABSTRACT: Background
Evidence suggests that the anatomic extent of metastatic lymph nodes (MLNs) affects prognosis, as proposed by alternative staging systems. The aim of this study was to establish a new staging system based on the number of perigastric (PMLN) and extra-perigastric (EMLN) MLNs.Methods
Data from a Chinese cohort of 1090 patients who had undergone curative gastrectomy with D2 or D2 plus lymphadenectomy for gastric cancer were retrospectively analysed. A Japanese validation cohort (n?=?826) was included. Based on the Cox proportional hazards model, the regression coefficients of PMLN and EMLN were used to calculate modified MLN (MMLN). Prognostic performance of the staging systems was evaluated.Results
PMLN and EMLN were independent prognostic factors in multivariate analysis (coefficients: 0.044, 0.115; all P?20).Discussion
The MMLN staging system is suitable for assessing overall survival among patients undergoing curative gastrectomy with D2 or D2 plus lymphadenectomy.
SUBMITTER: Li Z
PROVIDER: S-EPMC7921685 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Development and validation of a novel staging system integrating the number and location of lymph nodes for gastric adenocarcinoma.
British journal of cancer 20201202 5
<h4>Background</h4>Evidence suggests that the anatomic extent of metastatic lymph nodes (MLNs) affects prognosis, as proposed by alternative staging systems. The aim of this study was to establish a new staging system based on the number of perigastric (PMLN) and extra-perigastric (EMLN) MLNs.<h4>Methods</h4>Data from a Chinese cohort of 1090 patients who had undergone curative gastrectomy with D2 or D2 plus lymphadenectomy for gastric cancer were retrospectively analysed. A Japanese validation ...[more]