Alternative Pathway Involvement in Protoporphyria Patients Related to Sun Exposure.
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ABSTRACT:
SUBMITTER: Granata F
PROVIDER: S-EPMC7921788 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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Alternative Pathway Involvement in Protoporphyria Patients Related to Sun Exposure.
Granata Francesca F Duca Lorena L Brancaleoni Valentina V Fustinoni Silvia S De Luca Giacomo G Motta Irene I Graziadei Giovanna G Di Pierro Elena E
Frontiers in immunology 20210216
The homeostasis of tissues in a chronic disease is an essential function of the alternative pathway (AP) of the complement system (CS). However, if not controlled, it may also be detrimental to healthy cells with a consequent aggravation of symptoms. The protoporphyria (PP) is a rare chronic disease that causes phototoxicity in visible light with local skin pain and general malaise. In order to establish if there is a systemic involvement of the CS during sun exposure, we designed a non-invasive ...[more]
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