Ontology highlight
ABSTRACT:
SUBMITTER: Zimmermann A
PROVIDER: S-EPMC7921850 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zimmermann Andreas A Carmona-Gutierrez Didac D Madeo Frank F
Cell stress 20210308 3
The polyamine spermidine is essential for protein translation in eukaryotes, both as a substrate for the hypusination of the translation initiation factor eIF5A as well as general translational fidelity. Dwindling spermidine levels during aging have been implicated in reduced immune cell function through insufficient eIF5A hypusination, which can be restored by external supplementation. Recent findings characterize a group of novel Mendelian disorders linked to <i>EIF5A</i> missense and nonsense ...[more]