Ontology highlight
ABSTRACT:
SUBMITTER: Chinnici CM
PROVIDER: S-EPMC7922033 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Chinnici Cinzia Maria CM Iannolo Gioacchin G Cittadini Ettore E Carreca Anna Paola AP Nascari David D Timoneri Francesca F Bella Mariangela Di MD Cuscino Nicola N Amico Giandomenico G Carcione Claudia C Conaldi Pier Giulio PG
International journal of molecular sciences 20210219 4
Despite low levels of vascular endothelial growth factor (VEGF)-A, the secretome of human Wharton's jelly (WJ) mesenchymal stromal cells (MSCs) effectively promoted proangiogenic responses in vitro, which were impaired upon the depletion of small (~140 nm) extracellular vesicles (EVs). The isolated EVs shared the low VEGF-A profile of the secretome and expressed five microRNAs, which were upregulated compared to fetal dermal MSC-derived EVs. These upregulated microRNAs exclusively targeted the < ...[more]