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Chaperonins: Nanocarriers with Biotechnological Applications.

ABSTRACT: Chaperonins are molecular chaperones found in all kingdoms of life, and as such they assist in the folding of other proteins. Structurally, chaperonins are cylinders composed of two back-to-back rings, each of which is an oligomer of ~60-kDa proteins. Chaperonins are found in two main conformations, one in which the cavity is open and ready to recognise and trap unfolded client proteins, and a "closed" form in which folding takes place. The conspicuous properties of this structure (a cylinder containing a cavity that allows confinement) and the potential to control its closure and aperture have inspired a number of nanotechnological applications that will be described in this review.

SUBMITTER: Pipaon S

PROVIDER: S-EPMC7922521 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Chaperonins: Nanocarriers with Biotechnological Applications.

Pipaón Sergio S Gragera Marcos M Bueno-Carrasco M Teresa MT García-Bernalt Diego Juan J Cantero Miguel M Cuéllar Jorge J Fernández-Fernández María Rosario MR Valpuesta José María JM

Nanomaterials (Basel, Switzerland) 20210217 2

Chaperonins are molecular chaperones found in all kingdoms of life, and as such they assist in the folding of other proteins. Structurally, chaperonins are cylinders composed of two back-to-back rings, each of which is an oligomer of ~60-kDa proteins. Chaperonins are found in two main conformations, one in which the cavity is open and ready to recognise and trap unfolded client proteins, and a "closed" form in which folding takes place. The conspicuous properties of this structure (a cylinder co ...[more]

PMID: 33671209

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