Prognostic Gene Expression, Stemness and Immune Microenvironment in Pediatric Tumors.
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ABSTRACT:
SUBMITTER: Stahl D
PROVIDER: S-EPMC7922568 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Prognostic Gene Expression, Stemness and Immune Microenvironment in Pediatric Tumors.
Stahl David D Knoll Rainer R Gentles Andrew J AJ Vokuhl Christian C Buness Andreas A Gütgemann Ines I
Cancers 20210218 4
Pediatric tumors frequently arise from embryonal cells, often displaying a stem cell-like ("small round blue") morphology in tissue sections. Because recently "stemness" has been associated with a poor immune response in tumors, we investigated the association of prognostic gene expression, stemness and the immune microenvironment systematically using transcriptomes of 4068 tumors occurring mostly at the pediatric and young adult age. While the prognostic landscape of gene expression (PRECOG) an ...[more]
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