Ontology highlight
ABSTRACT:
SUBMITTER: Guerard A
PROVIDER: S-EPMC7922974 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Guérard Adrien A Laurent Victor V Fromont Gaëlle G Estève David D Gilhodes Julia J Bonnelye Edith E Le Gonidec Sophie S Valet Philippe P Malavaud Bernard B Reina Nicolas N Attané Camille C Muller Catherine C
International journal of molecular sciences 20210217 4
Bone metastasis remains the most frequent and the deadliest complication of prostate cancer (PCa). Mechanisms leading to the homing of tumor cells to bone remain poorly characterized. Role of chemokines in providing navigational cues to migrating cancer cells bearing specific receptors is well established. Bone is an adipocyte-rich organ since 50 to 70% of the adult bone marrow (BM) volume comprise bone marrow adipocytes (BM-Ads), which are likely to produce chemokines within the bone microenvir ...[more]