Ontology highlight
ABSTRACT:
SUBMITTER: Parrotta EI
PROVIDER: S-EPMC7923182 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Parrotta Elvira Immacolata EI Procopio Anna A Scalise Stefania S Esposito Claudia C Nicoletta Giovanni G Santamaria Gianluca G De Angelis Maria Teresa MT Dorn Tatjana T Moretti Alessandra A Laugwitz Karl-Ludwig KL Montefusco Francesco F Cosentino Carlo C Cuda Giovanni G
International journal of molecular sciences 20210218 4
Arrhythmogenic Right Ventricular cardiomyopathy (ARVC) is an inherited cardiac muscle disease linked to genetic deficiency in components of the desmosomes. The disease is characterized by progressive fibro-fatty replacement of the right ventricle, which acts as a substrate for arrhythmias and sudden cardiac death. The molecular mechanisms underpinning ARVC are largely unknown. Here we propose a mathematical model for investigating the molecular dynamics underlying heart remodeling and the loss o ...[more]