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The effects of BMMSC treatment on lung tissue degeneration in elderly macaques.

ABSTRACT:

Background

Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, cancer, among others). So, it is particularly important to find new anti-aging treatments.

Methods

We systematically screened and evaluated elderly senile multiple organ dysfunction macaque models to determine whether BMMSCs inhibited lung tissue degeneration.

Results

The average alveolar area, mean linear intercept (MLI), and fibrosis area in the elderly macaque models were significantly larger than in young rhesus monkeys (p?ConclusionsBMMSC treatment inhibited age-associated lung tissue degeneration.

SUBMITTER: Yang YK

PROVIDER: S-EPMC7923486 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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The effects of BMMSC treatment on lung tissue degeneration in elderly macaques.

Yang Yu-Kun YK Li Ye Y Wang Yan-Ying YY Ruan Guang-Ping GP Tian Chuan C Wang Qiang Q He Huan-Yu HY Zhu Gao-Hong GH Fang Dong D Wang Mao M Zhu Xiang-Qing XQ Pan Xing-Hua XH

Stem cell research & therapy 20210301 1

<h4>Background</h4>Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, cancer, among others). So, it is particularly important to find new anti-aging treatments.<h4>Methods</h4>We systematically screened and evaluated elderly senile multiple organ dysfunction macaque models to determine whether BMMSCs inhibited lung tissue degeneration.<h4>Res ...[more]

PMID: 33648583

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