Ontology highlight
ABSTRACT:
SUBMITTER: Li WC
PROVIDER: S-EPMC7923544 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Proceedings of the National Academy of Sciences of the United States of America 20210201 8
Most eukaryotes possess two RecA-like recombinases (ubiquitous Rad51 and meiosis-specific Dmc1) to promote interhomolog recombination during meiosis. However, some eukaryotes have lost Dmc1. Given that mammalian and yeast <i>Saccharomyces cerevisiae</i> (<i>Sc</i>) Dmc1 have been shown to stabilize recombination intermediates containing mismatches better than Rad51, we used the Pezizomycotina filamentous fungus <i>Trichoderma reesei</i> to address if and how Rad51-only eukaryotes conduct interho ...[more]