Ontology highlight
ABSTRACT:
SUBMITTER: Markowitsch SD
PROVIDER: S-EPMC7923752 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Markowitsch Sascha D SD Juetter Kira M KM Schupp Patricia P Hauschulte Kristine K Vakhrusheva Olesya O Slade Kimberly Sue KS Thomas Anita A Tsaur Igor I Cinatl Jindrich J Michaelis Martin M Efferth Thomas T Haferkamp Axel A Juengel Eva E
Cancers 20210220 4
The prognosis for advanced prostate carcinoma (PCa) remains poor due to development of therapy resistance, and new treatment options are needed. Shikonin (SHI) from Traditional Chinese Medicine has induced antitumor effects in diverse tumor entities, but data related to PCa are scarce. Therefore, the parental (=sensitive) and docetaxel (DX)-resistant PCa cell lines, PC3, DU145, LNCaP, and 22Rv1 were exposed to SHI [0.1-1.5 μM], and tumor cell growth, proliferation, cell cycling, cell death (apop ...[more]