Theoretical and experimental investigation of protein crystal nucleation in pores and crevices.
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ABSTRACT:
SUBMITTER: Nanev C
PROVIDER: S-EPMC7924239 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Theoretical and experimental investigation of protein crystal nucleation in pores and crevices.
Nanev Christo C Govada Lata L Chayen Naomi E NE
IUCrJ 20210211 Pt 2
The nucleation ability of pores is explained using the equilibration between the cohesive energy maintaining the integrity of a crystalline cluster and the destructive energy tending to tear it up. It is shown that to get 3D crystals it is vital to have 2D crystals nucleating in the pores first. By filling the pore orifice, the 2D crystal nuclei are more stable because their peripheries are protected from the destructive action of water molecules. Furthermore, the periphery of the 2D crystal is ...[more]
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