Ontology highlight
ABSTRACT:
SUBMITTER: Ruiu R
PROVIDER: S-EPMC7924390 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Ruiu Roberto R Barutello Giuseppina G Arigoni Maddalena M Riccardo Federica F Conti Laura L Peppino Giulia G Annaratone Laura L Marchiò Caterina C Mengozzi Giulio G Calogero Raffaele Adolfo RA Cavallo Federica F Quaglino Elena E
Cancers 20210220 4
Triple-negative breast cancer (TNBC) is insensitive to endocrine and Her2-directed therapies, making the development of TNBC-targeted therapies an unmet medical need. Since patients with TNBC frequently show a quicker relapse and metastatic progression compared to other breast cancer subtypes, we hypothesized that cancer stem cells (CSC) could have a role in TNBC. To identify putative TNBC CSC-associated targets, we compared the gene expression profiles of CSC-enriched tumorspheres and their par ...[more]