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New light shed on the early evolution of limb-bone growth plate and bone marrow.


ABSTRACT: The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells? Recent hypotheses suggested that haematopoiesis migrated into long bones prior to the water-to-land transition and protected newly-produced blood cells from harsher environmental conditions. However, little fossil evidence to support these hypotheses has been provided so far. Observations of the humeral microarchitecture of stem-tetrapods, batrachians, and amniotes were performed using classical sectioning and three-dimensional synchrotron virtual histology. They show that Permian tetrapods seem to be among the first to exhibit a centralised marrow organisation, which allows haematopoiesis as in extant amniotes. Not only does our study demonstrate that long-bone haematopoiesis was probably not an exaptation to the water-to-land transition but it sheds light on the early evolution of limb-bone development and the sequence of bone-marrow functional acquisitions.

SUBMITTER: Estefa J 

PROVIDER: S-EPMC7924947 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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New light shed on the early evolution of limb-bone growth plate and bone marrow.

Estefa Jordi J   Tafforeau Paul P   Clement Alice M AM   Klembara Jozef J   Niedźwiedzki Grzegorz G   Berruyer Camille C   Sanchez Sophie S  

eLife 20210302


The production of blood cells (haematopoiesis) occurs in the limb bones of most tetrapods but is absent in the fin bones of ray-finned fish. When did long bones start producing blood cells? Recent hypotheses suggested that haematopoiesis migrated into long bones prior to the water-to-land transition and protected newly-produced blood cells from harsher environmental conditions. However, little fossil evidence to support these hypotheses has been provided so far. Observations of the humeral micro  ...[more]

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