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Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses.


ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease of unknown cause. It has a high risk of rapid progression and mortality. We conducted a systematic review and meta-analysis to evaluate the risk factor of IPF. We searched Medline, Embase, and the Cochrane library from the earliest record to March, 2020. Case-control studies on occupational and environmental risk factors or on jobs with a risk of IPF were searched for. From 2490 relevant records, 12 studies were included. Any occupational or environmental exposure to metal dust (OR 1.83, 95% CI 1.15-2.91, I2?=?54%), wood dust (OR 1.62 5% CI 1.04-2.53, I2?=?5%) and pesticide (OR 2.07, 95% CI 1.24-3.45, I2?=?0%) were associated with an increased risk of IPF. Farming or agricultural work (OR 1.88, 95% CI 1.17-3.04, I2?=?67%) was also associated with an increased risk of IPF. Moreover, smoking increased IPF risk with an odds ratio of 1.39 (95% CI 1.01-1.91, I2?=?29%). In conclusion, metal dust, wood dust, pesticide, occupational history of farming or agriculture and ever smoking increased the risk of IPF.

SUBMITTER: Park Y 

PROVIDER: S-EPMC7925580 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses.

Park Yeonkyung Y   Ahn Chiwon C   Kim Tae-Hyung TH  

Scientific reports 20210302 1


Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease of unknown cause. It has a high risk of rapid progression and mortality. We conducted a systematic review and meta-analysis to evaluate the risk factor of IPF. We searched Medline, Embase, and the Cochrane library from the earliest record to March, 2020. Case-control studies on occupational and environmental risk factors or on jobs with a risk of IPF were searched for. From 2490 relevant records, 1  ...[more]

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