A Ten-N⁶-Methyladenosine (m⁶A)-Modified Gene Signature Based on a Risk Score System Predicts Patient Prognosis in Rectum Adenocarcinoma.

ABSTRACT:

Objectives

The study aims to analyze the expression of N⁶-methyladenosine (m⁶A)-modified genes in rectum adenocarcinoma (READ) and identify reliable prognostic biomarkers to predict the prognosis of READ.

Materials and methods

RNA sequence data of READ and corresponding clinical survival data were obtained from The Cancer Genome Atlas (TCGA) database. N⁶-methyladenosine (m⁶A)-modified genes in READ were downloaded from the "m6Avar" database. Differentially expressed m⁶A-modified genes in READ stratified by different clinicopathological characteristics were identified using the "limma" package in R. Protein-protein interaction (PPI) network and co-expression analysis of differentially expressed genes (DEGs) were performed

SUBMITTER: Huang W 

PROVIDER: S-EPMC7925823 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature