Ontology highlight
ABSTRACT:
SUBMITTER: Nancy Z
PROVIDER: S-EPMC7925991 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Nancy Zaarour Z Yan Li L Hui Shi S Paul Bowness B Liye Chen C
Frontiers in immunology 20210217
Genome-wide association studies (GWAS) have identified 113 single nucleotide polymorphisms (SNPs) affecting the risk of developing ankylosing spondylitis (AS), and an on-going GWAS study will likely identify 100+ new risk loci. The translation of genetic findings to novel disease biology and treatments has been difficult due to the following challenges: (1) difficulties in determining the causal genes regulated by disease-associated SNPs, (2) difficulties in determining the relevant cell-type(s) ...[more]