Ontology highlight
ABSTRACT:
SUBMITTER: Romani C
PROVIDER: S-EPMC7926503 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Romani Chiara C Capoferri Davide D Grillo Elisabetta E Silvestri Marco M Corsini Michela M Zanotti Laura L Todeschini Paola P Ravaggi Antonella A Bignotti Eliana E Odicino Franco F Sartori Enrico E Calza Stefano S Mitola Stefania S
Cancers 20210222 4
Claudin-low cancer (CL) represents a rare and biologically aggressive variant of epithelial tumor. Here, we identified a claudin-low molecular profile of ovarian high-grade serous carcinoma (HGSOC), which exhibits the main characteristics of the homonym breast cancer subtype, including low epithelial differentiation and high mesenchymal signature. Hierarchical clustering and a centroid based algorithm applied to cell line collection expression dataset labeled 6 HGSOC cell lines as CL. These have ...[more]