Ontology highlight
ABSTRACT:
SUBMITTER: Guo C
PROVIDER: S-EPMC7926937 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Guo Chenyun C Wu Zhihua Z Lin Weiliang W Xu Hao H Chang Ting T Dai Yazhuang Y Lin Donghai D
Molecules (Basel, Switzerland) 20210221 4
Suramin was initially used to treat African sleeping sickness and has been clinically tested to treat human cancers and HIV infection in the recent years. However, the therapeutic index is low with numerous clinical side-effects, attributed to its diverse interactions with multiple biological macromolecules. Here, we report a novel binding target of suramin, human Raf1 kinase inhibitory protein (hRKIP), which is an important regulatory protein involved in the Ras/Raf1/MEK/ERK (MAPK) signal pathw ...[more]