Ontology highlight
ABSTRACT:
SUBMITTER: Siddiqui FA
PROVIDER: S-EPMC7927014 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Siddiqui Farid Ahmad FA Parkkola Hanna H Vukic Vladimir V Oetken-Lindholm Christina C Jaiswal Alok A Kiriazis Alexandros A Pavic Karolina K Aittokallio Tero T Salminen Tiina A TA Abankwa Daniel D
Cancers 20210223 4
The ATP-competitive inhibitors of Hsp90 have been tested predominantly in kinase addicted cancers; however, they have had limited success. A mechanistic connection between Hsp90 and oncogenic K-Ras is not known. Here, we show that K-Ras selectivity is enabled by the loss of the K-Ras membrane nanocluster modulator galectin-3 downstream of the Hsp90 client HIF-1α. This mechanism suggests a higher drug sensitivity in the context of KRAS mutant, HIF-1α-high and/or Gal3-high cancer cells, such as th ...[more]