Differential Expression of BARD1 Isoforms in Melanoma.
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ABSTRACT:
SUBMITTER: McDougall LI
PROVIDER: S-EPMC7927127 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Differential Expression of <i>BARD1</i> Isoforms in Melanoma.
McDougall Lorissa I LI Powell Ryan M RM Ratajska Magdalena M Lynch-Sutherland Chi F CF Hossain Sultana Mehbuba SM Wiggins George A R GAR Harazin-Lechowska Agnieszka A Cybulska-Stopa Bożena B Motwani Jyoti J Macaulay Erin C EC Reid Glen G Walker Logan C LC Ryś Janusz J Eccles Michael R MR
Genes 20210223 2
Melanoma comprises <5% of cutaneous malignancies, yet it causes a significant proportion of skin cancer-related deaths worldwide. While new therapies for melanoma have been developed, not all patients respond well. Thus, further research is required to better predict patient outcomes. Using long-range nanopore sequencing, RT-qPCR, and RNA sequencing analyses, we examined the transcription of <i>BARD1</i> splice isoforms in melanoma cell lines and patient tissue samples. Seventy-six <i>BARD1</i> ...[more]
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