Ontology highlight
ABSTRACT:
SUBMITTER: Jiang L
PROVIDER: S-EPMC7927154 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Jiang Liwei L Wang Yi-Jun YJ Zhao Jing J Uehara Mayuko M Hou Qingming Q Kasinath Vivek V Ichimura Takaharu T Banouni Naima N Dai Li L Li Xiaofei X Greiner Dale L DL Shultz Leonard D LD Zhang Xiaolong X Sun Zhen-Yu Jim ZJ Curtin Ian I Vangos Nicholas E NE Yeoh Zoe C ZC Geffken Ezekiel A EA Seo Hyuk-Soo HS Liu Ze-Xian ZX Heffron Gregory J GJ Shah Khalid K Dhe-Paganon Sirano S Abdi Reza R
Cell 20201101 5
Cancer therapies kill tumors either directly or indirectly by evoking immune responses and have been combined with varying levels of success. Here, we describe a paradigm to control cancer growth that is based on both direct tumor killing and the triggering of protective immunity. Genetic ablation of serine protease inhibitor SerpinB9 (Sb9) results in the death of tumor cells in a granzyme B (GrB)-dependent manner. Sb9-deficient mice exhibited protective T cell-based host immunity to tumors in a ...[more]