Decreasing brain iron in multiple sclerosis: The difference between concentration and content in iron MRI.

ABSTRACT: Increased brain iron concentration is often reported concurrently with disease development in multiple sclerosis (MS) and other neurodegenerative diseases. However, it is unclear whether the higher iron concentration in patients stems from an influx of iron into the tissue or a relative reduction in tissue compartments without much iron. By taking into account structural volume, we investigated tissue iron content in the deep gray matter (DGM) over 2 years, and compared findings to previously reported changes in iron concentration. 120 MS patients and 40 age- and sex-matched healthy controls were included. Clinical testing and MRI were performed both at baseline and after 2 years. Overall, iron content was calculated from structural MRI and quantitative susceptibility mapping in the thalam

SUBMITTER: Schweser F 

PROVIDER: S-EPMC7927296 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature