ERG11 Polymorphism in Voriconazole-Resistant Candida tropicalis: Weak Role of ERG11 Expression, Ergosterol Content, and Membrane Permeability.
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SUBMITTER: Navarro-Rodriguez P
PROVIDER: S-EPMC7927814 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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<i>ERG11</i> Polymorphism in Voriconazole-Resistant Candida tropicalis: Weak Role of <i>ERG11</i> Expression, Ergosterol Content, and Membrane Permeability.
Navarro-Rodríguez Patricia P López-Fernández Loida L Martin-Vicente Adela A Guarro Josep J Capilla Javier J
Antimicrobial agents and chemotherapy 20201216 1
Mutations in <i>ERG11</i> were detected by gene sequencing and amino acid alignment in 18 <i>Candida tropicalis</i> strains with different degrees of sensitivity to voriconazole (VRC). <i>ERG11</i> expression, sterol content, and membrane permeability were also evaluated. We report three missense mutations in <i>ERG11</i> that resulted in resistance to VRC. The transcriptional levels of <i>ERG11</i> as well as the ergosterol content and membrane permeability demonstrated no correlation to only a ...[more]
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