Telomere Maintenance Variants and Survival after Colorectal Cancer: Smoking- and Sex-Specific Associations.

ABSTRACT:

Background

Telomeres play an important role in colorectal cancer prognosis. Variation in telomere maintenance genes may be associated with survival after colorectal cancer diagnosis, but evidence is limited. In addition, possible interactions between telomere maintenance genes and prognostic factors, such as smoking and sex, also remain to be investigated.

Methods

We conducted gene-wide analyses of colorectal cancer prognosis in 4,896 invasive colorectal cancer cases from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO); 1,871 common variants within 13 telomere maintenance genes were included. Cox models were fit to estimate associations of these variants individually with overall and colorectal cancer-specific survival. Likelihood ratio tests were used

SUBMITTER: Yin H 

PROVIDER: S-EPMC7928192 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature